Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols

Endonuclease III, encoded by nth in Escherichia coli, removes thymine glycols (Tg), a toxic oxidative DNA lesion. To determine the biological significance of this repair in mammals, we established a mouse model with mutated mNth1, a homolog of nth, by gene targeting. The homozygous mNth1 mutant mice...

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Main Authors: Takao, Masashi, Kanno, Shin-ichiro, Shiromoto, Tatsuya, Hasegawa, Rei, Ide, Hiroshi, Ikeda, Shogo, Sarker, Altraf H., Seki, Shuji, Xing, James Z., Le, X.Chris, Weinfeld, Michael, Kobayashi, Kumiko, Miyazaki, Jun-ichi, Muijtjens, Manja, Hoeijmakers, Jan H.J., van der Horst, Gijsbertus, Yasui, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125395/
https://ncbi.nlm.nih.gov/pubmed/12093749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf350
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