Spi-B can functionally replace PU.1 in myeloid but not lymphoid development

Mature macrophages, neutrophils and lymphoid cells do not develop in PU.1(–/–) mice. In contrast, mice lacking the highly related protein Spi-B generate all hematopoietic lineages but display a B-cell receptor signaling defect. These distinct phenotypes could result from functional differences betwe...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Dahl, Richard, Ramirez-Bergeron, Diana L., Rao, Sridhar, Simon, M.Celeste
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11980719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.9.2220
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