Spi-B can functionally replace PU.1 in myeloid but not lymphoid development
Mature macrophages, neutrophils and lymphoid cells do not develop in PU.1(–/–) mice. In contrast, mice lacking the highly related protein Spi-B generate all hematopoietic lineages but display a B-cell receptor signaling defect. These distinct phenotypes could result from functional differences betwe...
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| Yayımlandı: | EMBO J |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125373/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11980719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.9.2220 |
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