GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice

Visual transduction in retinal photoreceptors operates through a dynamic interplay of two second messengers, Ca(2+) and cGMP. Ca(2+) regulates the activity of guanylate cyclase (GC) and the synthesis of cGMP by acting on a GC-activating protein (GCAP). While this action is critical for rapid termina...

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Main Authors: Howes, Kim A., Pennesi, Mark E., Sokal, Izabela, Church-Kopish, Jill, Schmidt, Ben, Margolis, David, Frederick, Jeanne M., Rieke, Fred, Palczewski, Krzysztof, Wu, Samuel M., Detwiler, Peter B., Baehr, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125366/
https://ncbi.nlm.nih.gov/pubmed/11927539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.7.1545
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