Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA(A) receptors regulates the efficacy of inhibitory synaptic transmission

The efficacy of synaptic inhibition depends on the number of γ-aminobutyric acid type A receptors (GABA(A)Rs) expressed on the cell surface of neurons. The clathrin adaptor protein 2 (AP2) complex is a critical regulator of GABA(A)R endocytosis and, hence, surface receptor number. Here, we identify...

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Hlavní autoři: Kittler, Josef T., Chen, Guojun, Honing, Stephan, Bogdanov, Yury, McAinsh, Kristina, Arancibia-Carcamo, I. Lorena, Jovanovic, Jasmina N., Pangalos, Menelas N., Haucke, Volker, Yan, Zhen, Moss, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2005
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253579/
https://ncbi.nlm.nih.gov/pubmed/16192353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506653102
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