A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis

cAMP plays crucial roles in cardiac remodeling and the progression of heart failure. Recently, we found that expression of cAMP hydrolyzing phosphodiesterase 3A (PDE3A) was significantly reduced in human failing hearts, accompanied by up-regulation of inducible cAMP early repressor (ICER) expression...

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Detalhes bibliográficos
Main Authors: Ding, Bo, Abe, Jun-ichi, Wei, Heng, Xu, Haodong, Che, Wenyi, Aizawa, Toru, Liu, Weimin, Molina, Carlos A., Sadoshima, Junichi, Blaxall, Burns C., Berk, Bradford C., Yan, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253575/
https://ncbi.nlm.nih.gov/pubmed/16186489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506489102
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