A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis

cAMP plays crucial roles in cardiac remodeling and the progression of heart failure. Recently, we found that expression of cAMP hydrolyzing phosphodiesterase 3A (PDE3A) was significantly reduced in human failing hearts, accompanied by up-regulation of inducible cAMP early repressor (ICER) expression...

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Bibliografiske detaljer
Main Authors: Ding, Bo, Abe, Jun-ichi, Wei, Heng, Xu, Haodong, Che, Wenyi, Aizawa, Toru, Liu, Weimin, Molina, Carlos A., Sadoshima, Junichi, Blaxall, Burns C., Berk, Bradford C., Yan, Chen
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253575/
https://ncbi.nlm.nih.gov/pubmed/16186489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506489102
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