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Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6·U5 tri-snRNP formation and pre-mRNA splicing
In each round of nuclear pre-mRNA splicing, the U4/U6·U5 tri-snRNP must be assembled from U4/U6 and U5 snRNPs, a reaction that is at present poorly understood. We have characterized a 61 kDa protein (61K) found in human U4/U6·U5 tri-snRNPs, which is homologous to yeast Prp31p, and show that it is re...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125353/ https://ncbi.nlm.nih.gov/pubmed/11867543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.5.1148 |
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