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Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA

The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved ∼40-residue ‘LEM’ motif. Loss of emerin causes Emery–Dreifuss muscular dystrophy. We have solved the solution NMR structure of the constant region of human LAP2 (residues 1–168). Human LAP2(1–168) has two structurally independent,...

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Autores principales: Cai, Mengli, Huang, Ying, Ghirlando, Rodolfo, Wilson, Katherine L., Craigie, Robert, Clore, G.Marius
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC125263/
https://ncbi.nlm.nih.gov/pubmed/11500367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.16.4399
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