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Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA
The nuclear envelope proteins LAP2, emerin and MAN1 share a conserved ∼40-residue ‘LEM’ motif. Loss of emerin causes Emery–Dreifuss muscular dystrophy. We have solved the solution NMR structure of the constant region of human LAP2 (residues 1–168). Human LAP2(1–168) has two structurally independent,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125263/ https://ncbi.nlm.nih.gov/pubmed/11500367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.16.4399 |
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