Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1

The trimeric Cdk7–cyclin H–Mat1 complex comprises the kinase subunit of basal transcription factor TFIIH and has been shown to function as a cyclin-dependent kinase (Cdk)-activating kinase. Herein we report that disruption of the murine Mat1 gene leads to peri-implantation lethality coincident with...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Rossi, Derrick J., Londesborough, Anou, Korsisaari, Nina, Pihlak, Arno, Lehtonen, Eero, Henkemeyer, Mark, Mäkelä, Tomi P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125252/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11387217/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.11.2844
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