Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

Studies have shown that clusterin (also called apolipoprotein J) can influence the structure and toxicity of amyloid-β (Aβ) in vitro. To determine whether endogenous clusterin plays a role in influencing Aβ deposition, structure, and toxicity in vivo, we bred PDAPP mice, a transgenic mouse model of...

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Detalhes bibliográficos
Main Authors: DeMattos, Ronald B., O'dell, Mark A., Parsadanian, Maia, Taylor, Jennie W., Harmony, Judith A. K., Bales, Kelly R., Paul, Steven M., Aronow, Bruce J., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125060/
https://ncbi.nlm.nih.gov/pubmed/12145324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162228299
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