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A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease
The principle that developmentally silenced globin genes can be reactivated in adults with defects in β-globin gene expression has been well established both in vitro and in vivo. In practice, levels of developmental stage-discordant fetal γ globin that can be achieved by using currently approved th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124997/ https://ncbi.nlm.nih.gov/pubmed/12124399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162269099 |
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