GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid

OBJECTIVES: Lithium (Li(+)) has been suggested to target the enzyme glycogen synthase kinase 3 (GSK-3) as a mechanism of mood stabilization. Inhibition of GSK-3 by a second mood-stabilizer, valproic acid (VPA), has also been reported, but this effect is dependent on cell type. It is currently unknow...

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Main Authors: Ryves, W Jonathan, Dalton, Emma C, Harwood, Adrian J, Williams, Robin SB
Format: Artigo
Sprog:Inglês
Udgivet: 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1249491/
https://ncbi.nlm.nih.gov/pubmed/15898963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1399-5618.2005.00194.x
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