An Endoplasmic Reticulum-Targeting Signal Sequence Enhances the Immunogenicity of an Immunorecessive Simian Virus 40 Large T Antigen Cytotoxic T-Lymphocyte Epitope

An immunological hierarchy among three H-2D(b)-restricted cytotoxic T lymphocyte (CTL) determinants in simian virus 40 (SV40) large T antigen (Tag) was described previously: determinants I and II/III are immunodominant, whereas determinant V is immunorecessive. To assess the immunogenicity of each d...

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Main Authors: Fu, Tong-Ming, Mylin, Lawrence M., Schell, Todd D., Bacik, Igor, Russ, Gustav, Yewdell, Jonathan W., Bennink, Jack R., Tevethia, Satvir S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC124628/
https://ncbi.nlm.nih.gov/pubmed/9445050
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