Variant-type PML-RARα fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RARα gene and identification of a new clinical subtype resistant to retinoic acid therapy

The physiologic actions of retinoic acids (RAs) are mediated through RA receptors (RARs) and retinoid X receptors (RXRs). The RARα gene has drawn particular attention because it is the common target in all chromosomal translocations in acute promyelocytic leukemia (APL), a unique model in cancer res...

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Библиографические подробности
Главные авторы: Gu, Bai-Wei, Xiong, Hui, Zhou, Yan, Chen, Bing, Wang, Li, Dong, Shuo, Yu, Zhi-Yuan, Lu, Ling-Feng, Zhong, Ming, Yin, Hai-Feng, Zhu, Gen-Feng, Huang, Wei, Ren, Shuang-Xi, Gallagher, Robert E., Waxman, Samuel, Chen, Guo-Qiang, Wang, Zhu-Gang, Chen, Zhu, Fu, Gang, Chen, Sai-Juan
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2002
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC124308/
https://ncbi.nlm.nih.gov/pubmed/12032336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.112194799
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