BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

Loss of function of BRCA1 caused by inherited mutation and tissue-specific somatic mutation leads to breast and ovarian cancer. Nearly all BRCA1 germ-line mutations involve truncation or loss of the C-terminal BRCT transcriptional activation domain, suggesting that transcriptional regulation is a cr...

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Hlavní autoři: Welcsh, Piri L., Lee, Ming K., Gonzalez-Hernandez, Rachel M., Black, Daniel J., Mahadevappa, Mamatha, Swisher, Elizabeth M., Warrington, Janet A., King, Mary-Claire
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC124283/
https://ncbi.nlm.nih.gov/pubmed/12032322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.062181799
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