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Use of gene expression profiling to direct in vivo molecular imaging of lung cancer

Using gene expression profiling, we identified cathepsin cysteine proteases as highly up-regulated genes in a mouse model of human lung adenocarcinoma. Overexpression of cathepsin proteases in these lung tumors was confirmed by immunohistochemistry and Western blotting. Therefore, an optical probe a...

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Main Authors: Grimm, Jan, Kirsch, David G., Windsor, Stephen D., Kim, Carla F. Bender, Santiago, Philip M., Ntziachristos, Vasilis, Jacks, Tyler, Weissleder, Ralph
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242291/
https://ncbi.nlm.nih.gov/pubmed/16183744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503920102
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