Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease

Frequently, mtDNA with pathogenic mutations coexist with wild-type genomes (mtDNA heteroplasmy). Mitochondrial dysfunction and disease ensue only when the proportion of mutated mtDNAs is high, thus a reduction in this proportion should provide an effective therapy for these disorders. We developed a...

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Autores principales: Bayona-Bafaluy, Maria Pilar, Blits, Bas, Battersby, Brendan J., Shoubridge, Eric A., Moraes, Carlos T.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2005
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242285/
https://ncbi.nlm.nih.gov/pubmed/16179392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502896102
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