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Intersheet rearrangement of polypeptides during nucleation of β-sheet aggregates
Many neurodegenerative diseases are characterized by the accumulation of amyloid fibers in the brain, which can occur when a protein misfolds into an extended β-sheet conformation. The nucleation of these β-sheet aggregates is of particular interest, not only because it is the rate-determining step...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242284/ https://ncbi.nlm.nih.gov/pubmed/16176990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502804102 |
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