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Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus
Breach of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus (SLE). However, how B cell tolerance is subverted in human SLE is poorly understood due to difficulties in identifying relevant autoreactive B cells and in obtaining lymphoid tissue. We have circumvented these...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242189/ https://ncbi.nlm.nih.gov/pubmed/16211091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24179 |
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