Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus

Breach of B cell tolerance is central to the pathogenesis of systemic lupus erythematosus (SLE). However, how B cell tolerance is subverted in human SLE is poorly understood due to difficulties in identifying relevant autoreactive B cells and in obtaining lymphoid tissue. We have circumvented these...

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Библиографические подробности
Главные авторы: Cappione, Amedeo, Anolik, Jennifer H., Pugh-Bernard, Aimee, Barnard, Jennifer, Dutcher, Paul, Silverman, Gregg, Sanz, Iñaki
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2005
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1242189/
https://ncbi.nlm.nih.gov/pubmed/16211091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24179
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