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Agonist-induced PIP(2) Hydrolysis Inhibits Cortical Actin Dynamics: Regulation at a Global but not at a Micrometer Scale
Phosphatidylinositol 4, 5-bisphosphate (PIP(2)) at the inner leaflet of the plasma membrane has been proposed to locally regulate the actin cytoskeleton. Indeed, recent studies that use GFP-tagged pleckstrin homology domains (GFP-PH) as fluorescent PIP(2) sensors suggest that this lipid is enriched...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The American Society for Cell Biology
2002
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC124157/ https://ncbi.nlm.nih.gov/pubmed/12221130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-04-0231 |
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