Molecular Evolution of Aromatic Polyketides and Comparative Sequence Analysis of Polyketide Ketosynthase and 16S Ribosomal DNA Genes from Various Streptomyces Species

A 613-bp fragment of an essential ketosynthase gene from the biosynthetic pathway of aromatic polyketide antibiotics was sequenced from 99 actinomycetes isolated from soil. Phylogenetic analysis showed that the isolates clustered into clades that correspond to the various classes of aromatic polyket...

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Bibliographic Details
Main Authors: Metsä-Ketelä, Mikko, Halo, Laura, Munukka, Eveliina, Hakala, Juha, Mäntsälä, Pekka, Ylihonko, Kristiina
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC124067/
https://ncbi.nlm.nih.gov/pubmed/12200302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.68.9.4472-4479.2002
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