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In vitro selection of RNA aptamers against a composite small molecule-protein surface

A particularly challenging problem in chemical biology entails developing systems for modulating the activity of RNA using small molecules. One promising new approach towards this problem exploits the phenomenon of ‘surface borrowing,’ in which the small molecule is presented to the RNA in complex w...

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Detalhes bibliográficos
Main Authors: Plummer, Kelly A., Carothers, James M., Yoshimura, Masahiro, Szostak, Jack W., Verdine, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240114/
https://ncbi.nlm.nih.gov/pubmed/16199752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki867
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