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Dual roles for cholesterol in mammalian cells

The structural features of sterols required to support mammalian cell growth have not been fully defined. Here, we use mutant CHO cells that synthesize only small amounts of cholesterol to test the capacity of various sterols to support growth. Sterols with minor modifications of the side chain (e.g...

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Autori principali: Xu, Fang, Rychnovsky, Scott D., Belani, Jitendra D., Hobbs, Helen H., Cohen, Jonathan C., Rawson, Robert B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1239893/
https://ncbi.nlm.nih.gov/pubmed/16199524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503590102
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