Reversal of experimental pulmonary hypertension by PDGF inhibition

Progression of pulmonary hypertension is associated with increased proliferation and migration of pulmonary vascular smooth muscle cells. PDGF is a potent mitogen and involved in this process. We now report that the PDGF receptor antagonist STI571 (imatinib) reversed advanced pulmonary vascular dise...

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Hauptverfasser: Schermuly, Ralph Theo, Dony, Eva, Ghofrani, Hossein Ardeschir, Pullamsetti, Soni, Savai, Rajkumar, Roth, Markus, Sydykov, Akylbek, Lai, Ying Ju, Weissmann, Norbert, Seeger, Werner, Grimminger, Friedrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2005
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236676/
https://ncbi.nlm.nih.gov/pubmed/16200212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24838
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