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Leukotriene A(4) hydrolase: Selective abrogation of leukotriene B(4) formation by mutation of aspartic acid 375

Leukotriene A(4) (LTA(4), 5S-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid) hydrolase (LTA4H)/aminopeptidase is a bifunctional zinc metalloenzyme that catalyzes the final and rate-limiting step in the biosynthesis of leukotriene B(4) (LTB(4), 5S,12R-dihydroxy-6,14-cis-8,10-trans-eicosate...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rudberg, Peter C., Tholander, Fredrik, Thunnissen, Marjolein M. G. M., Samuelsson, Bengt, Haeggström, Jesper Z.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123628/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11917124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.072090099
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