Precise Estimation of Allele Frequencies of Single-Nucleotide Polymorphisms by a Quantitative SSCP Analysis of Pooled DNA

We show that single-nucleotide polymorphisms (SNPs) of moderate to high heterozygosity (minor allele frequencies >10%) can be efficiently detected, and their allele frequencies accurately estimated, by pooling the DNA samples and applying a capillary-based SSCP analysis. In this method, alleles a...

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Autori principali: Sasaki, Tomonari, Tahira, Tomoko, Suzuki, Akari, Higasa, Koichiro, Kukita, Yoji, Baba, Shingo, Hayashi, Kenshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Human Genetics 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234915/
https://ncbi.nlm.nih.gov/pubmed/11083945
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