Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses

In response to transforming growth factor β (TGF-β), Smad4 forms complexes with activated Smad2 and Smad3, which accumulate in the nucleus, where they both positively and negatively regulate TGF-β target genes. Mutation or deletion of Smad4 is found in about 50% of pancreatic tumors and in about 15%...

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Hlavní autoři: Levy, Laurence, Hill, Caroline S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234333/
https://ncbi.nlm.nih.gov/pubmed/16135802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8108-8125.2005
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