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Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

Recent investigation has focused on identifying signaling pathways that inhibit cardiac hypertrophy, a major risk factor for cardiovascular morbidity and mortality. In this context, nitric oxide (NO), signaling via cGMP and cGMP-dependent protein kinase type I (PKG I), has been recognized as a negat...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Fiedler, Beate, Lohmann, Suzanne M., Smolenski, Albert, Linnemüller, Stephan, Pieske, Burkert, Schröder, Frank, Molkentin, Jeffery D., Drexler, Helmut, Wollert, Kai C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177418/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162100799
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