Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

The Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency disorder caused by a mutation in WAS protein (WASp) that results in defective actin polymerization. Although the function of many hematopoietic cells requires WASp, the specific expression and function of this molecule in natural kille...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Orange, Jordan S., Ramesh, Narayanaswamy, Remold-O'Donnell, Eileen, Sasahara, Yoji, Koopman, Louise, Byrne, Michael, Bonilla, Francisco A., Rosen, Fred S., Geha, Raif S., Strominger, Jack L.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 2002
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC123260/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177428/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162376099
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Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

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