Wiskott–Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses

The Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency disorder caused by a mutation in WAS protein (WASp) that results in defective actin polymerization. Although the function of many hematopoietic cells requires WASp, the specific expression and function of this molecule in natural kille...

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Detalhes bibliográficos
Main Authors: Orange, Jordan S., Ramesh, Narayanaswamy, Remold-O'Donnell, Eileen, Sasahara, Yoji, Koopman, Louise, Byrne, Michael, Bonilla, Francisco A., Rosen, Fred S., Geha, Raif S., Strominger, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123260/
https://ncbi.nlm.nih.gov/pubmed/12177428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.162376099
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