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Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

During paroxysmal neocortical oscillations, sudden depolarization leading to the next cycle occurs when the majority of cortical neurons are hyperpolarized. Both the Ca(2+)-dependent K(+) currents (I(K(Ca))) and disfacilitation play critical roles in the generation of hyperpolarizing potentials. In...

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Detalhes bibliográficos
Main Authors: Timofeev, Igor, Bazhenov, Maxim, Sejnowski, Terrence, Steriade, Mircea
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123175/
https://ncbi.nlm.nih.gov/pubmed/12089324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132259899
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