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Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

During paroxysmal neocortical oscillations, sudden depolarization leading to the next cycle occurs when the majority of cortical neurons are hyperpolarized. Both the Ca(2+)-dependent K(+) currents (I(K(Ca))) and disfacilitation play critical roles in the generation of hyperpolarizing potentials. In...

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Autors principals: Timofeev, Igor, Bazhenov, Maxim, Sejnowski, Terrence, Steriade, Mircea
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC123175/
https://ncbi.nlm.nih.gov/pubmed/12089324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132259899
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