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Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

During paroxysmal neocortical oscillations, sudden depolarization leading to the next cycle occurs when the majority of cortical neurons are hyperpolarized. Both the Ca(2+)-dependent K(+) currents (I(K(Ca))) and disfacilitation play critical roles in the generation of hyperpolarizing potentials. In...

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Bibliographische Detailangaben
Hauptverfasser: Timofeev, Igor, Bazhenov, Maxim, Sejnowski, Terrence, Steriade, Mircea
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC123175/
https://ncbi.nlm.nih.gov/pubmed/12089324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132259899
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