The Apoptotic Response to Pneumolysin Is Toll-Like Receptor 4 Dependent and Protects against Pneumococcal Disease

Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to pneumococcal infection via its interaction with pneumolysin, but the underlying mechanisms remain to be identi...

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Auteurs principaux: Srivastava, Amit, Henneke, Philipp, Visintin, Alberto, Morse, Sarah C., Martin, Victoria, Watkins, Claire, Paton, James C., Wessels, Michael R., Golenbock, Douglas T., Malley, Richard
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Host Response and Inflammation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230904/
https://ncbi.nlm.nih.gov/pubmed/16177320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6479-6487.2005
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