Working Mechanism of Immunoglobulin A1 (IgA1) Protease: Cleavage of IgA1 Antibody to Neisseria meningitidis PorA Requires De Novo Synthesis of IgA1 Protease

Neisseria meningitidis secretes a protease that specifically cleaves the hinge region of immunoglobulin A1 (IgA1), releasing the effector (Fc) domain of IgA1 from the antigen binding (Fab) determinants. Theoretically, the remaining Fab fragments can block pathogen receptors or toxins and still provi...

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Autori principali: Vidarsson, Gestur, Overbeeke, Natasja, Stemerding, Annette M., van den Dobbelsteen, Germie, van Ulsen, Peter, van der Ley, Peter, Kilian, Mogens, van de Winkel, Jan G. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230903/
https://ncbi.nlm.nih.gov/pubmed/16177349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6721-6726.2005
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