Working Mechanism of Immunoglobulin A1 (IgA1) Protease: Cleavage of IgA1 Antibody to Neisseria meningitidis PorA Requires De Novo Synthesis of IgA1 Protease

Neisseria meningitidis secretes a protease that specifically cleaves the hinge region of immunoglobulin A1 (IgA1), releasing the effector (Fc) domain of IgA1 from the antigen binding (Fab) determinants. Theoretically, the remaining Fab fragments can block pathogen receptors or toxins and still provi...

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Detalhes bibliográficos
Main Authors: Vidarsson, Gestur, Overbeeke, Natasja, Stemerding, Annette M., van den Dobbelsteen, Germie, van Ulsen, Peter, van der Ley, Peter, Kilian, Mogens, van de Winkel, Jan G. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230903/
https://ncbi.nlm.nih.gov/pubmed/16177349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6721-6726.2005
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