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Enterotoxin-Based Mucosal Adjuvants Alter Antigen Trafficking and Induce Inflammatory Responses in the Nasal Tract

The safety of nasal vaccines containing enterotoxin-based mucosal adjuvants has not been studied in detail. Previous studies have indicated that native cholera toxin (nCT) can alter antigen trafficking when applied nasally. In this study, we determined the enterotoxin-based variables that alter anti...

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Detalhes bibliográficos
Main Authors: van Ginkel, Frederik W., Jackson, Raymond J., Yoshino, Naoto, Hagiwara, Yukari, Metzger, Daniel J., Connell, Terry D., Vu, Hong L., Martin, Michael, Fujihashi, Kohtaro, McGhee, Jerry R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230900/
https://ncbi.nlm.nih.gov/pubmed/16177369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6892-6902.2005
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