A Second Generation of Double Mutant Cholera Toxin Adjuvants: Enhanced Immunity without Intracellular Trafficking

Nasal application of native cholera toxin (nCT) as a mucosal adjuvant has potential toxicity for the CNS through binding to GM1 gangliosides in the olfactory nerves. Although mutants of cholera toxin (mCTs) have been developed that show mucosal adjuvant activity without toxicity, it still remains un...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hagiwara, Yukari, Kawamura, Yuki I., Kataoka, Kosuke, Rahima, Bibi, Jackson, Raymond J., Komase, Katsuhiro, Dohi, Taeko, Boyaka, Prosper N., Takeda, Yoshifumi, Kiyono, Hiroshi, McGhee, Jerry R., Fujihashi, Kohtaro
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469177/
https://ncbi.nlm.nih.gov/pubmed/16920941
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