Biochemical Characterization and Vaccine Potential of a Heme-Binding Glutathione Transferase from the Adult Hookworm Ancylostoma caninum

We report the cloning and expression of Ac-GST-1, a novel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in parasite blood feeding and as a vaccine target. The predicted Ac-GST-1 open reading frame contains 207 amino acids (mass, 24 kDa) and exhibited up...

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Autori principali: Zhan, Bin, Liu, Sen, Perally, Samirah, Xue, Jian, Fujiwara, Ricardo, Brophy, Peter, Xiao, Shuhua, Liu, Yueyuan, Feng, Jianjun, Williamson, Angela, Wang, Yan, Bueno, Lilian L., Mendez, Susana, Goud, Gaddam, Bethony, Jeffrey M., Hawdon, John M., Loukas, Alex, Jones, Karen, Hotez, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1230892/
https://ncbi.nlm.nih.gov/pubmed/16177370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.10.6903-6911.2005
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