An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

The vanilloid receptor VR1 is a nonselective cation channel that is most abundant in peripheral sensory fibers but also is found in several brain nuclei. VR1 is gated by protons, heat, and the pungent ingredient of “hot” chili peppers, capsaicin. To date, no endogenous compound with potency at this...

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Detalhes bibliográficos
Main Authors: Huang, Susan M., Bisogno, Tiziana, Trevisani, Marcello, Al-Hayani, Abdulmonem, De Petrocellis, Luciano, Fezza, Filomena, Tognetto, Michele, Petros, Timothy J., Krey, Jocelyn F., Chu, Constance J., Miller, Jeffrey D., Davies, Stephen N., Geppetti, Pierangelo, Walker, J. Michael, Di Marzo, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123079/
https://ncbi.nlm.nih.gov/pubmed/12060783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122196999
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