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In vitro and in vivo studies of a VEGF(121)/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors
Vascular endothelial growth factor (VEGF) plays a key role in the growth and metastasis of solid tumors. We generated a fusion protein containing VEGF(121) linked by a flexible G(4)S tether to the toxin gelonin (rGel) and expressed this as a soluble protein in bacteria. Purified VEGF(121)/rGel migra...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122986/ https://ncbi.nlm.nih.gov/pubmed/12060733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122157899 |
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