In vitro and in vivo studies of a VEGF(121)/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

Vascular endothelial growth factor (VEGF) plays a key role in the growth and metastasis of solid tumors. We generated a fusion protein containing VEGF(121) linked by a flexible G(4)S tether to the toxin gelonin (rGel) and expressed this as a soluble protein in bacteria. Purified VEGF(121)/rGel migra...

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Détails bibliographiques
Auteurs principaux: Veenendaal, Liesbeth M., Jin, Hangqing, Ran, Sophia, Cheung, Lawrence, Navone, Nora, Marks, John W., Waltenberger, Johannes, Thorpe, Philip, Rosenblum, Michael G.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2002
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC122986/
https://ncbi.nlm.nih.gov/pubmed/12060733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.122157899
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