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Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response

The cellular response to low tissue oxygen concentrations is mediated by the hypoxia-inducible transcription factor HIF-1. Under hypoxic conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its α-subunit (H...

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Main Authors: Dames, Sonja A., Martinez-Yamout, Maria, De Guzman, Roberto N., Dyson, H. Jane, Wright, Peter E.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC122759/
https://ncbi.nlm.nih.gov/pubmed/11959977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082121399
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