The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1

Cell cycle checkpoints are evolutionarily conserved surveillance systems that protect genomic stability and prevent oncogenesis in mammals. One important target of checkpoint control is ribonucleotide reductase (RNR), which catalyzes the rate-limiting step in dNTP and DNA synthesis. In both yeast an...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Zhao, Xiaolan, Rothstein, Rodney
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062502299
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