Structural studies of the scrapie prion protein by electron crystallography

Because the insolubility of the scrapie prion protein (PrP(Sc)) has frustrated structural studies by x-ray crystallography or NMR spectroscopy, we used electron crystallography to characterize the structure of two infectious variants of the prion protein. Isomorphous two-dimensional crystals of the...

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Autors principals: Wille, Holger, Michelitsch, Melissa D., Guénebaut, Vincent, Supattapone, Surachai, Serban, Ana, Cohen, Fred E., Agard, David A., Prusiner, Stanley B.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC122563/
https://ncbi.nlm.nih.gov/pubmed/11891310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052703499
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