Structural studies of the scrapie prion protein by electron crystallography

Because the insolubility of the scrapie prion protein (PrP(Sc)) has frustrated structural studies by x-ray crystallography or NMR spectroscopy, we used electron crystallography to characterize the structure of two infectious variants of the prion protein. Isomorphous two-dimensional crystals of the...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wille, Holger, Michelitsch, Melissa D., Guénebaut, Vincent, Supattapone, Surachai, Serban, Ana, Cohen, Fred E., Agard, David A., Prusiner, Stanley B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122563/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11891310/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052703499
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