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How the folding rate constant of simple, single-domain proteins depends on the number of native contacts

Experiments have shown that the folding rate constants of two dozen structurally unrelated, small, single-domain proteins can be expressed in terms of one quantity (the contact order) that depends exclusively on the topology of the folded state. Such dependence is unique in chemical kinetics. Here w...

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Detalles Bibliográficos
Main Authors: Makarov, Dmitrii E., Keller, Craig A., Plaxco, Kevin W., Metiu, Horia
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC122558/
https://ncbi.nlm.nih.gov/pubmed/11904417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052713599
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