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Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes

Bunyaviruses replicate in the cytoplasm of infected cells. New viral particles are formed by budding of nucleocapsids into the Golgi apparatus. We have previously shown that the IFN-induced human MxA protein inhibits bunyavirus replication by an unknown mechanism. Here we demonstrate that MxA binds...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kochs, Georg, Janzen, Christian, Hohenberg, Heinz, Haller, Otto
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122488/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880649/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052430399
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