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The antimalarial drug artemisinin alkylates heme in infected mice
Heme alkylation by the antimalarial drug artemisinin is reported in vivo, within infected mice that have been treated at pharmacologically relevant doses. Adducts resulting from the alkylation of heme by the drug were characterized in the spleen of treated mice, and their glucuroconjugated derivativ...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224611/ https://ncbi.nlm.nih.gov/pubmed/16155128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500972102 |
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